MOTS-C 10 mg

Dragon Pharma MOTS-C 10 mg: The Revolutionary Mitochondrial Peptide for Metabolic Mastery

Dragon Pharma MOTS-C 10 mg represents a groundbreaking advancement in peptide therapy, targeting the very core of cellular energy and metabolism. MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a unique, mitochondria-derived peptide that acts as a powerful regulator of metabolic homeostasis. Unlike nuclear DNA-encoded peptides, MOTS-C is encoded within the mitochondrial genome and released in response to metabolic stress, such as exercise and caloric restriction. This 10 mg vial of pure, lyophilized peptide provides a potent dose to harness these innate protective mechanisms. MOTS-C works by optimizing the balance between glucose and fatty acid metabolism, enhancing insulin sensitivity, and promoting cellular resilience. For bodybuilders, athletes, and longevity enthusiasts, MOTS-C offers a sophisticated approach to improving body composition, boosting exercise performance, and supporting healthy aging from the cellular level upward.

Effects and Benefits of MOTS-C

MOTS-C operates through a unique mechanism that mimics the beneficial effects of exercise and fasting at a molecular level. Its primary action involves the activation of the AMPK pathway (AMP-activated protein kinase), a key cellular energy sensor. This activation shifts the body's metabolism towards more efficient energy utilization, leading to enhanced insulin sensitivity and improved glucose uptake into muscles, which is crucial for both performance and fat loss. One of the most significant benefits is the prevention of age-dependent and diet-induced insulin resistance, making it easier to maintain a lean physique. MOTS-C also promotes fatty acid oxidation, encouraging the body to use stored fat for energy. Beyond metabolism, it enhances physical performance by increasing endurance and exercise capacity, likely through improved mitochondrial efficiency and reduced fatigue. Furthermore, MOTS-C has demonstrated neuroprotective effects and may support cognitive health. For those seeking to combat the metabolic slowdown that can occur with age or during extensive cutting phases, MOTS-C provides a powerful, systemic solution. The pioneering research on MOTS-c has highlighted its critical role in metabolic regulation, showing its ability to reverse diet-induced obesity and insulin resistance in animal models.

Dosage and Administration Protocol

Dragon Pharma MOTS-C 10 mg is supplied as a lyophilized powder that must be reconstituted with Bacteriostatic Water before use. As a relatively new peptide, dosing protocols are still being refined, but established ranges have shown efficacy.

Reconstitution: Inject 1-2 mL of Bacteriostatic Water into the vial. Gently swirl until the powder is completely dissolved; do not shake. Store the reconstituted solution in the refrigerator.

Common Dosing Protocol: MOTS-C has a relatively long half-life, allowing for less frequent dosing compared to many other peptides. A common and effective protocol involves administering 5-10 mg, 2-3 times per week. This means one 10 mg vial provides 1-2 doses. Injections are typically performed subcutaneously (SubQ). Some users prefer to administer doses on non-consecutive days (e.g., Monday, Wednesday, Friday). For a more aggressive approach, particularly for addressing significant insulin resistance or during a intense cutting phase, doses of 5 mg every other day can be used. Cycles typically last 6-12 weeks, followed by a break of equal length.

Incorporating MOTS-C into Your Metabolic and Performance Protocol

MOTS-C is a versatile foundational peptide that excels in various stacks, particularly those focused on metabolic health, endurance, and longevity.

• The Ultimate Metabolic Optimization Stack: For profound improvements in insulin sensitivity and body recomposition, MOTS-C can be stacked with other insulin-sensitizing agents. Combining it with L-Carnitine 500 ensures that fats are both mobilized and efficiently burned for energy. Adding Berberine can create a powerful synergy for glucose control.
• Endurance and Performance Stack: To dramatically enhance workout capacity and recovery, stack MOTS-C with other endurance-enhancing compounds. GW501516 (Cardarine) is an excellent partner, as both compounds enhance fatty acid oxidation and mitochondrial function, allowing for longer, more intense training sessions.
• Longevity and Anti-Aging Stack: For a comprehensive anti-aging protocol, MOTS-C serves as a cornerstone. It can be combined with other longevity peptides like Epitalon 50 mg for telomere support and GHK-cu 50 mg for systemic tissue repair and collagen production, addressing aging from multiple angles.
• Cutting Cycle Support: During a calorie-restricted cutting phase, MOTS-C is invaluable for preserving metabolic rate and insulin sensitivity. It helps prevent the metabolic adaptation that often stalls fat loss. It pairs well with fat-burning agents like Clenbuterol or the appetite suppressant effects of Mazdutide, ensuring your body remains metabolically flexible and efficient at burning fat.

Possible Side Effects and Safety

MOTS-C is considered to have an excellent safety profile, largely because it mimics a naturally occurring signaling molecule that the body produces under healthy conditions like exercise.

• Minimal to No Side Effects: In both research and user reports, significant adverse effects are exceedingly rare. It does not produce the nausea, flushing, or hunger changes associated with many other peptides.
• No Hormonal Effects: MOTS-C works entirely on metabolic pathways and does not influence the HPTA axis. It has no androgenic, estrogenic, or progestogenic activity, making it safe for both men and women.
• No Impact on Blood Pressure or Heart Rate: Unlike stimulant-based fat burners, MOTS-C does not increase heart rate or blood pressure. Its actions are metabolic and cellular, not neurological or cardiovascular.
• Hypoglycemia Potential: As with any compound that improves insulin sensitivity, there is a theoretical risk of lowered blood sugar, especially in individuals who are already lean or using other glucose-lowering agents. However, this is uncommon at standard doses.
• Injection Site Reactions: As with any injectable, mild redness, swelling, or itching at the injection site may occur but is typically transient.
• No Liver or Kidney Toxicity: MOTS-C is a peptide that is broken down into natural amino acids and does not present any hepatotoxicity or nephrotoxicity.

The exceptional tolerability of MOTS-C makes it suitable for long-term use and for individuals who are sensitive to the side effects of other performance-enhancing or metabolic compounds.

MOTS-C Profile

Name: Mitochondrial Open Reading Frame of the 12S rRNA-c
Drug Class: Mitochondrial-Derived Peptide (MDP)
Other common names and terms: MOTS-c, Mitochondrial Peptide
Active Life: Several days
Detection Time: Approximately 1 week
Chemical Structure: 16-amino acid peptide (MRWQEMGYIFYPRKLR)
Common Doses: 5-10 mg, 2-3 times per week
Blood pressure: No significant effect; may support healthy blood pressure
Acne: No
Water retention: No
Aromatisation: No
Liver toxicity: None
Decrease HPTA function: No