Mazdutide 10 mg

Dragon Pharma Mazdutide 10 mg: The Next-Generation Dual Agonist for Unprecedented Weight Loss

Dragon Pharma Mazdutide 10 mg represents the cutting edge of metabolic peptide therapy, offering a sophisticated dual-mechanism approach that surpasses single-action GLP-1 agonists. Also known as IBI362, Mazdutide is a novel, long-acting dual agonist that simultaneously activates both the Glucagon-like Peptide-1 (GLP-1) receptor and the Glucagon (GCGR) receptor. This powerful dual-action creates a synergistic effect that not only suppresses appetite and slows gastric emptying like traditional GLP-1 drugs but also significantly increases energy expenditure through glucagon receptor activation. With third-party lab verification confirming 9.11 mg of high-purity peptide per vial, this product delivers reliable, research-backed potency. For bodybuilders, athletes, and individuals seeking dramatic body recomposition, Mazdutide offers a comprehensive metabolic solution that targets both sides of the energy balance equation: reducing caloric intake while increasing caloric expenditure.

Effects and Benefits of Mazdutide

Mazdutide's dual-receptor activation produces a comprehensive array of metabolic benefits that make it exceptionally effective for weight loss and body recomposition. Through GLP-1 receptor agonism, it powerfully suppresses appetite by increasing feelings of fullness and satiety, leading to a natural reduction in caloric intake without the struggle of willpower. It also slows gastric emptying, which helps maintain stable blood sugar levels and prolongs the sensation of fullness after meals. The glucagon receptor activation is what sets Mazdutide apart, as it increases energy expenditure by stimulating thermogenesis and promoting lipolysis—the breakdown of stored fat for energy. This means your body burns more calories even at rest. Additionally, Mazdutide improves insulin sensitivity and glucose control, making it particularly beneficial for those with metabolic syndrome or prediabetes. Users experience rapid and significant reductions in body weight, with clinical studies showing superior weight loss compared to GLP-1 agonists alone. The clinical efficacy of dual GLP-1/glucagon receptor agonists has been demonstrated in research, showing their potential to produce substantial weight loss and metabolic improvements.

Dosage and Administration Protocol

Dragon Pharma Mazdutide 10 mg is supplied as a lyophilized powder that must be reconstituted with Bacteriostatic Water before use. As a long-acting peptide, it requires only weekly administration, making it highly convenient.

Reconstitution: Inject 1-2 mL of Bacteriostatic Water into the vial. Gently swirl until the powder is completely dissolved; do not shake. Once reconstituted, store the vial in the refrigerator.

Common Dosing Protocol: Mazdutide is typically administered once per week via subcutaneous (SubQ) injection. For beginners, it is crucial to start with a low dose to assess tolerance. A common titration schedule begins with 1-2 mg per week for the first 2-4 weeks, gradually increasing by 1-2 mg every 2-4 weeks as tolerated. The maintenance dose typically ranges from 4-6 mg weekly, with some advanced users going up to 8-10 mg. The 10 mg vial provides flexibility for various dosing protocols. Injection sites should be rotated between the abdomen, thighs, and upper arms.

Incorporating Mazdutide into Your Body Recomposition Protocol

Mazdutide is a powerful foundational compound for any cutting or recomposition phase. Its ability to create a significant calorie deficit makes it highly synergistic with other fat-loss agents.

• Advanced Metabolic Stack: For maximum fat loss, Mazdutide can be stacked with other metabolic enhancers. Combining it with L-Carnitine 500 ensures that the fat mobilized through increased energy expenditure is efficiently transported into mitochondria and burned for fuel.
• Cutting Cycle Synergy: During a traditional cutting cycle with anabolic agents, Mazdutide can help achieve extreme leanness. It pairs exceptionally well with compounds known for producing a hard, dry look, such as Masteron 100 or Winstrol 50, by ensuring a significant calorie deficit is maintained.
• Pre-Contest Fine-Tuning: In the final weeks before a competition, Mazdutide can be invaluable for shedding the last layers of stubborn fat. Its appetite suppression makes dieting more manageable, while its metabolic effects ensure continued fat loss. It can be used alongside a thyroid hormone like T3 for a powerful metabolic boost.
• Post-Cycle Weight Management: After a mass-building cycle, Mazdutide can help manage the rebound in body fat that often occurs during the Post-Cycle Therapy (PCT) period when hormones are fluctuating. It can help maintain a lean physique while the HPTA axis recovers, especially when used with PCT staples like Clomid and Nolvadex.

Possible Side Effects and Safety

As a potent metabolic agent, Mazdutide can produce side effects, particularly during the dose-titration phase. Most are gastrointestinal and tend to diminish with continued use.

• Gastrointestinal Issues: The most common side effects are nausea, vomiting, diarrhea, and constipation. These are typically dose-dependent and most pronounced when starting the peptide or increasing the dose. Taking the injection with a light meal and staying hydrated can help mitigate these effects.
• Decreased Appetite: While this is a desired effect for weight loss, it can be pronounced. It is crucial to prioritize protein intake and nutrient-dense foods to prevent muscle loss, especially for athletes.
• Hypoglycemia: By improving insulin sensitivity and slowing gastric emptying, Mazdutide can lower blood sugar levels. Individuals on diabetes medication or those who are very lean should monitor their blood glucose, especially around workouts.
• Gallbladder Issues: Rapid weight loss from any cause can increase the risk of gallstones. Staying adequately hydrated and incorporating healthy fats into the diet may help reduce this risk.
• Injection Site Reactions: Mild redness, swelling, or itching at the injection site may occur but usually resolves quickly.
• No Hormonal Effects: Mazdutide does not affect the HPTA axis, does not aromatize, and has no androgenic properties. It is not liver toxic.

Starting with a low dose and titrating up slowly is the most effective strategy for managing side effects and allowing the body to adapt.

Mazdutide Profile

Name: Mazdutide (IBI362)
Drug Class: Dual GLP-1 and Glucagon Receptor Agonist
Other common names and terms: IBI362, OXM3
Active Life: ~5-7 days (allowing for once-weekly dosing)
Detection Time: Several weeks
Chemical Structure: Long-acting oxyntomodulin analog (dual GLP-1/GCGR agonist)
Common Doses: 2-6 mg, once per week (titrated from a lower starting dose)
Blood pressure: Can cause a slight decrease, often a beneficial effect
Acne: No
Water retention: No
Aromatisation: No
Liver toxicity: None reported; may improve liver enzymes in individuals with NAFLD
Decrease HPTA function: No

Third Party Lab Test Results

2024-09-13

View Result

9.11 mg