NAD+ 100 mg

NAD+: The Master Coenzyme for Cellular Energy, Recovery, and Anti-Aging

Nicotinamide Adenine Dinucleotide (NAD+) is not just another supplement; it is a fundamental coenzyme present in every single cell of your body, essential for life itself. As the central conductor of cellular metabolism, NAD+ levels profoundly influence energy production, DNA repair, and the aging process. Peptide Hubs offers a high-purity 100 mg vial of NAD+ in lyophilized form, providing researchers with a direct method to study the impact of elevating this critical molecule on physical performance, cognitive function, and overall cellular health.

What is NAD+?

NAD+ is a crucial coenzyme found in all living cells. It exists in two forms: NAD+ (oxidized) and NADH (reduced). This dynamic duo acts as a shuttle bus for electrons, playing a pivotal role in redox reactions, most notably in the mitochondria during cellular respiration. Here, it helps convert nutrients from food into adenosine triphosphate (ATP), the primary energy currency of the cell. Beyond energy metabolism, NAD+ serves as a essential substrate for several key enzymes, including sirtuins (SIRTs), which are proteins linked to longevity and DNA repair, and poly (ADP-ribose) polymerases (PARPs), which are critical for DNA repair. The decline of NAD+ with age is considered a hallmark of the aging process, contributing to reduced energy, slower recovery, and increased susceptibility to age-related diseases. For a foundational scientific overview, refer to the NAD+ compound summary on PubChem.

Effects of NAD+

Elevating NAD+ levels through supplementation can have wide-ranging, systemic effects that are highly relevant to athletes and anyone seeking to optimize their health and performance.

• Enhanced Cellular Energy Production: By directly fueling the electron transport chain in the mitochondria, NAD+ supplementation can lead to a significant increase in ATP production, resulting in reduced fatigue and improved endurance and stamina.
• Accelerated Muscle Recovery: NAD+ supports the activation of sirtuins and PARPs, which play roles in cellular repair processes. This can lead to faster recovery from intense training, reduced muscle soreness, and decreased inflammation.
• Improved Cognitive Function and Mental Clarity: The brain is an energy-intensive organ. Boosting NAD+ levels supports neuronal health, enhances neuroplasticity, and can improve focus, memory, and overall cognitive performance.
• Powerful Anti-Aging and Cellular Repair: By activating sirtuins, NAD+ promotes DNA repair, supports healthy cellular senescence, and upregulates mitochondrial biogenesis (the creation of new mitochondria), countering key aspects of cellular aging.
• Enhanced Metabolic Health: NAD+ is crucial for metabolic flexibility—the body's ability to efficiently switch between burning carbohydrates and fats for fuel. This can support healthier body composition and insulin sensitivity.
• Neuroprotection and Mood Support: Research suggests NAD+ may support the brain's resilience to stress and help maintain healthy neurotransmitter balance, contributing to improved mood and neurological well-being.

Dosage and Administration

NAD+ is typically reconstituted with Bac Water and is most effectively administered via intramuscular (IM) or subcutaneous (SubQ) injection for research purposes. Intravenous administration is used clinically but is not practical for most research settings.

• Common Research Dosage: Doses in research protocols typically range from 50 mg to 200 mg, administered 2-3 times per week. A common starting point is 100 mg every other day or 3 times weekly.
• Cycle Length: Given its role as a fundamental cellular cofactor, NAD+ is suitable for both short-term "booster" cycles and longer-term maintenance protocols. Cycles of 4-8 weeks are common for intensive research, with options for ongoing lower-dose maintenance.
• Timing: Administration in the morning is often preferred to align with the body's natural circadian rhythm and to provide a boost in energy and mental clarity for the day. Some researchers also explore pre-workout administration to directly support energy production during exercise.
• Note on Sensations: Some researchers report a transient "flushing" sensation or mild nausea immediately following injection, which typically subsides within 15-30 minutes. Starting with a lower dose can help assess tolerance.

NAD+ Cycle Guide

NAD+'s fundamental role in cellular function makes it an excellent foundational component in a research stack, synergizing with peptides that target specific pathways like growth hormone, metabolism, and cellular repair.

• NAD+ Solo Energy & Recovery Cycle: 100 mg, administered 3 times per week for 6-8 weeks. Ideal for researching its core effects on energy, cognitive function, and systemic recovery.
• The Ultimate Anti-Aging & Longevity Stack: Combine with Epitalon 50 mg to target telomere health and with Humanin 10 mg for mitochondrial protection, creating a comprehensive cellular rejuvenation protocol.
• Advanced Metabolic & Performance Stack: Stack with MOTS-c 10 mg, another mitochondrial peptide, to powerfully activate the AMPK pathway and synergistically enhance endurance, fat loss, and insulin sensitivity.
• Cognitive Enhancement & Neuroprotection Protocol: For focused brain health research, combine with N-Acetyl Semax Amidate 30 mg to boost BDNF and cognitive function, and Selank 10 mg for anxiolytic support.
• Growth Hormone & Recovery Amplification Stack: Pair with CJC-1295/Ipamorelin to provide the cellular energy (NAD+) needed to maximize the anabolic and recovery benefits of increased Growth Hormone pulsatility.
• Comprehensive Detox & Liver Health Stack: Combine with L-Glutathione 600 mg to support the body's primary antioxidant systems and liver detoxification pathways, which are heavily dependent on NAD+.

Possible Side Effects

NAD+ is generally well-tolerated, especially when started at a moderate dose. Most side effects are mild and transient.

• Transient Flushing and Nausea: This is the most common side effect, often described as a warm, flushing sensation in the face and upper body, sometimes accompanied by mild nausea. It typically begins a few minutes after injection and subsides within 15-30 minutes.
• Lightheadedness or Dizziness: Some individuals may experience brief lightheadedness, which usually resolves quickly.
• Injection Site Discomfort: As with any injection, minor redness, swelling, or tenderness can occur. This is more common with intramuscular injections.
• Headache: A mild, temporary headache can occur in some cases.
• Chest Tightness or "Air Hunger": A less common but reported sensation is a temporary feeling of chest tightness or difficulty taking a deep breath, which resolves rapidly.
• No Hormonal Interference: NAD+ does not suppress the HPTA axis and has no known androgenic or estrogenic activity.

Reconstitution and Storage

Your Peptide Hubs NAD+ 100 mg vial arrives as a lyophilized powder. To reconstitute, gently inject 2-3 mL of Bacteriostatic Water into the vial, aiming the stream against the glass wall. Roll the vial gently between your hands until the powder is fully dissolved and the solution is clear. Do not shake vigorously, as this can potentially degrade the molecule. Once reconstituted, the solution must be refrigerated and used within a few weeks. Unreconstituted vials should be stored in a refrigerator, protected from light, to ensure long-term stability of this sensitive molecule.

NAD+ 100 mg Profile

Name: Nicotinamide Adenine Dinucleotide
Drug Class: Essential Coenzyme / Nucleotide
Other common names and terms: NAD, Coenzyme 1, Oxidized Nicotinamide Adenine Dinucleotide
Active Life: Several hours (exact half-life in circulation is short, but cellular effects are sustained)
Detection Time: Not established; likely very short.
Chemical Structure: C21H27N7O14P2
Common Doses: 50-200 mg, 2-3 times per week
Blood pressure: No significant negative impact; may have a beneficial effect.
Acne: No
Water retention: No
Aromatisation: No (does not convert to estrogen)
Liver toxicity: No evidence of hepatotoxicity; is hepatoprotective.
Decrease HPTA function: No

Third Party Lab Test Results

2025-09-29

View Result

114.47 mg