MOTS-c 10 mg

MOTS-c: The Revolutionary Mitochondrial Peptide for Endurance, Fat Loss, and Metabolic Mastery

MOTS-c stands at the forefront of a new era in peptide science, representing a paradigm shift in our understanding of cellular energy and metabolism. Unlike traditional peptides encoded by nuclear DNA, MOTS-c is encoded within the mitochondrial genome itself, acting as a powerful signaling molecule that coordinates metabolic homeostasis. Peptide Hubs offers a premium 10 mg vial of this groundbreaking peptide, verified by third-party lab testing, providing researchers with a pure and potent tool to explore the intricate links between mitochondrial function, exercise performance, and age-related metabolic decline.

What is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a recently discovered, 16-amino acid peptide that is encoded in the mitochondrial DNA and expressed in various tissues. Its discovery challenged the long-held belief that the mitochondrial genome only encoded proteins for the electron transport chain. MOTS-c functions as a mitochondrial signal to the nucleus, influencing gene expression to optimize metabolic function under stress conditions. Its primary mechanism involves activating the AMPK pathway, a central regulator of cellular energy often called the "metabolic master switch." This pathway is famously activated by exercise and metformin. By mimicking this state, MOTS-c promotes glucose uptake and fatty acid oxidation while inhibiting the folate cycle and de novo purine synthesis, which shifts the body's metabolism. For foundational scientific research, you can explore the seminal 2015 study on MOTS-c published in Cell Metabolism.

Effects of MOTS-c

The effects of MOTS-c are profound and systemic, targeting the very core of cellular energy production and utilization. This makes it a subject of intense interest for researchers in sports performance, obesity, and aging.

• Significantly Enhanced Endurance and Exercise Capacity: MOTS-c improves skeletal muscle function and efficiency, leading to remarkable increases in running distance, grip strength, and overall physical performance in research models, without an increase in training.
• Powerful Insulin Sensitization and Glucose Metabolism: It promotes glucose uptake into muscles, improving insulin sensitivity and helping to maintain healthy blood sugar levels, making it a key peptide for metabolic syndrome research.
• Promotion of Lean Body Mass and Fat Loss: By shifting energy utilization towards fatty acid oxidation and improving metabolic flexibility, MOTS-c promotes a reduction in fat mass while helping to preserve, or even increase, lean muscle mass.
• Robust Anti-Aging and Cellular Protection: MOTS-c levels naturally decline with age. Supplementation has been shown to counteract age-dependent and diet-induced insulin resistance and obesity, positioning it as a powerful "exercise mimetic" that conveys the systemic benefits of physical activity.
• Reduction of Oxidative Stress: The peptide helps to reduce cellular oxidative damage, a key contributor to aging and various chronic diseases, by optimizing mitochondrial function.
• Improved Bone Density: Emerging research suggests that MOTS-c may play a role in bone metabolism, potentially helping to maintain bone density and strength.

Dosage and Administration

MOTS-c is typically reconstituted with Bac Water and administered via subcutaneous (SubQ) injection. As a relatively new peptide, research protocols are still being refined, but established dosing ranges have shown efficacy and safety in preclinical models.

• Common Research Dosage: A standard research dose ranges from 5 mg to 10 mg, administered 2-3 times per week. Some protocols utilize a dose of 5 mg every other day.
• Cycle Length: Given its role in metabolic regulation and its excellent safety profile, MOTS-c is well-suited for longer research cycles. Cycles of 8-12 weeks are common, followed by a break of 4-6 weeks to maintain optimal cellular responsiveness.
• Timing: Administration can be done at any time of day. Some researchers prefer to inject in the morning to align with the body's natural metabolic rhythms, while others administer pre-workout to potentially enhance exercise performance.
• Note on Dosing: The 10 mg vial from Peptide Hubs is perfectly sized for single-use administration according to these protocols, ensuring accurate dosing and convenience.

MOTS-c Cycle Guide

MOTS-c's unique mechanism makes it an excellent base for stacks aimed at comprehensive body recomposition, performance enhancement, and longevity.

• MOTS-c Solo Metabolic Reset Cycle: 5-10 mg, administered 2-3 times per week for 8-12 weeks. Ideal for researching its core effects on insulin sensitivity, endurance, and body composition.
• The Ultimate Endurance & Performance Stack: Combine with AICAR 50 mg, another AMPK activator, to create a powerful synergistic effect that dramatically boosts endurance, stamina, and fat utilization.
• Advanced Body Recomposition Protocol: Stack with Tesamorelin 5 mg to powerfully target stubborn visceral fat while leveraging MOTS-c's insulin-sensitizing and muscle-preserving properties.
• Comprehensive Anti-Aging & Recovery Stack: For a full-spectrum approach, combine with Humanin 10 mg (another mitochondrial-derived peptide) and Epitalon 50 mg to support cellular health, telomere maintenance, and systemic rejuvenation.
• Lean Mass and Strength Optimization: Pair with IGF-1 LR3 1 mg to create a powerful anabolic environment for muscle growth, while MOTS-c ensures the metabolic efficiency to support it without excess fat gain.
• Cognitive & Metabolic Enhancement: Stack with NAD+ 100 mg to provide the essential cofactor for mitochondrial energy production, potentially amplifying MOTS-c's benefits on energy, metabolism, and cognitive function.

Possible Side Effects

MOTS-c is renowned for its exceptional safety profile. As an endogenous peptide (naturally produced in the body), it is generally very well-tolerated in research settings with a low incidence of side effects.

• Minimal to No Side Effects: The vast majority of research indicates no significant adverse effects, even at higher doses. Its action mimics natural metabolic pathways, making it a very "physiological" intervention.
• Theoretical Hypoglycemia: Due to its potent insulin-sensitizing effects, there is a theoretical risk of lowered blood glucose levels. However, this is rarely reported in practice.
• Injection Site Reactions: As with any subcutaneous injection, minor redness, itching, or swelling at the injection site can occur, but this is typically mild and transient.
• No Hormonal Interference: MOTS-c does not interact with the hypothalamic-pituitary-gonadal (HPG) axis, meaning it does not cause suppression of natural testosterone production or other hormonal imbalances.
• No Appetite Stimulation or Suppression: Unlike some other metabolic peptides, MOTS-c does not appear to have a direct impact on appetite.

Reconstitution and Storage

Your Peptide Hubs MOTS-c 10 mg vial arrives as a lyophilized powder. To reconstitute, gently inject 1-2 mL of Bacteriostatic Water into the vial, directing the stream against the glass wall to avoid damaging the fragile peptide structure. Roll the vial gently between your hands until the solution is clear and all powder is dissolved. Do not shake. Once reconstituted, store the vial in a refrigerator and use it within a few weeks for optimal potency. Unreconstituted vials should be stored in a cool, dark place, ideally refrigerated, for long-term stability.

MOTS-c 10 mg Profile

Name: MOTS-c
Drug Class: Mitochondrial-Derived Peptide (MDP)
Other common names and terms: Mitochondrial ORF of the Twelve S rRNA-c
Active Life: Estimated several days (research ongoing)
Detection Time: Not established; likely short due to peptide nature.
Chemical Structure: 16-amino acid peptide (MW: 1874 g/mol)
Common Doses: 5-10 mg, 2-3 times per week
Blood pressure: No significant impact; may have a beneficial effect.
Acne: No
Water retention: No
Aromatisation: No (does not convert to estrogen)
Liver toxicity: No evidence of hepatotoxicity; may be hepatoprotective.
Decrease HPTA function: No

Third Party Lab Test Results

2025-10-01

View Result

9.73 mg